P(RNCH2CH2)3N-Catalyzed Synthesis of β-Hydroxy Nitriles
- 1 April 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 64 (9) , 3090-3094
- https://doi.org/10.1021/jo981858y
Abstract
We herein report the successful synthesis of beta-hydroxy nitriles in very good to excellent yields from aldehydes and ketones in a simple reaction that is promoted by strong nonionic bases of the title type. The reaction occurs in the presence of magnesium salts which activate the carbonyl group and stabilizes the enolate thus produced.Keywords
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