OBSERVATIONS ON INULIN AND DIODRAST CLEARANCES AND ON RENAL PLASMA FLOW IN NORMAL AND HYPOPHYSECTOMIZED DOGS

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Abstract
Diodrast plasma clearance in dogs has averaged 246 cc./min./M2 at plasma I levels between 1.3 and 13 mg. per 100 cc; the clearance falls progressively at higher levels. Tubular output of D rises linearly with increasing plasma level up to about 13 mg. I per 100 cc; here the slope begins to fall and the curve becomes horizontal at about 20 mg. Diodrast Tm, being attained at a plasma level of 20 mg. I, averages 22.4 mg. I/min./M2. True RPF is obtained, usually within 10%, by multiplying D plasma clearance, obtained at plasma I levels between 1.3 and 13 mg., by 1.2. Renal plasma flow averaged 325, renal blood flow 655 cc./min./M2. About 11% of the D entering the urine comes from the blood cells. The filtration fraction of plasma averaged 0.28. The inulin and D plasma clearances and the rate of tubular output of D in the hypophysectomized dog are about half the normal. This indicates a low RPF with an essentially normal filtration fraction.