EFFECT OF SKIN ALLOGRAFT IMMUNIZATION ON THE MIXED LEUKOCYTE REACTION OF THE CLAWED FROG, XENOPUS LAEVIS

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Abstract
One-way mixed leukocyte reactions (MLR) of responder spleen cells from frogs (X. laevis) that had rejected skin grafts were examined. Maximum and median stimulation indices (SI) of cultures that contained responder cells from the graft recipient and stimulator cells from the graft donor were significantly greater than the peak and median SI of cultures in which the responder splenocytes were from control, non-immune animals. Significant stimulation was recorded earlier (day 2 of culture) in more cultures involving immune responder cells than in control cultures. This earlier and greater proliferation in MLR was antigen specific.