COMPARISON OF MODE OF IMMUNOPOTENTIATING ACTION OF BCG AND WAX-D .1. EFFECT ON IMMUNE-RESPONSE TO SRBC

  • 1 January 1977
    • journal article
    • research article
    • Vol. 47  (3) , 163-168
Abstract
The immunopotentiating action of BCG and wax D was comparatively evaluated as the immune response to sheep red blood cells (SRBC) in mice. The immunopotentiation of BCG varied with the interval between its priming and subsequent antigen injection. BCG increased delayed type hypersensitivity (DTH) at an early stage but enhanced antibody formation at a later stage. DTH reached its maximum about 5 wk after BCG inoculation. Wax D increased antibody formation at an early stage but increased DTH at a later stage. Freund''s complete adjuvant (FCA) containing wax D stimulated antibody formation rather than induction of DTH in mice. Cord factor and even Drakerol 6VR could induce DTH at early stage of prior inoculation.