Extended Therapy with Intravenous Arginine Butyrate in Patients with β-Hemoglobinopathies

Open Access
Publisher Website
Google Scholar
Abstract
Enhanced production of fetal hemoglobin lessens the severity of β-thalassemia and sickle cell disease. Intravenous infusion of arginine butyrate can increase the number of reticulocytes containing fetal hemoglobin in patients with these disorders, and it has induced a substantial increase in hemoglobin in one patient with thalassemia. We therefore tested the efficacy of this agent in patients with β-hemoglobinopathies.