Free Plasma Levels and Urinary Excretion of Eighteen Amino Acids in Normal and Diabetic Dogs

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Abstract
Data have been compiled on the total urinary and plasma free amino acids of dogs rendered diabetic through pancreatectomy or admn. of alloxan. These values were compared with those obtained on the same animals prior to production of the diabetic state. Four behavior patterns were exhibited among the plasma amino acids. Only leucine, isoleucine and valine exhibited fasting plasma levels that were significantly above their normal range. During uncontrolled diabetes the 24 hour total urinary excretion of 15 out of 18 amino acids was significantly elevated. Only tryptophan, methionine and cystine were not increased significant-ly in the urine during periods of uncontrolled alloxan and pan-createctomy diabetes. Evidence is presented which suggests that an increased formation of glycine and some other amino acids may occur during uncontrolled diabetes.