THE RENAL AMINO ACID CLEARANCE IN THE NORMAL DOG

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Abstract
The urinary excretion and reabsorption of [alpha]-amino acid following oral and intraven. adm. of dl-alanine and of casein hydrolysate, with plasma levels of a-amino acid N up to 10 times the normal value, follow a uniform pattern in the normal dog. At normal plasma amino acid N conc. the renal amino acid clearance was usually less than 1 ml./sq. m./min. Progressive increase in the amt. of amino acids excreted in the urine paralleled the rise in plasma amino acid N conc. with resultant high amino acid clearances. The efficiency of the renal tubules in reabsorption of amino acids from the glomerular filtrate was remarkable; even at very high plasma amino acid N concs. as much as 64-81% was reabsorbed. A maximal rate of tubular transfer was not demonstrated for either substance at the plasma concs. attained, and there was no evidence of tubular ex-cretion of amino acids. The ratio urea clearance/creatinine clearance remained fixed during the progressive increase in both plasma amino acid and urea cones. In contrast the ratio amino acid clearance/creatinine clearance increased with the rise in plasma amino acid.

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