Interleukin-2 can induce proliferation of leukemic B-cells in prolymphocytic leukemia

24 April 2009

journal article
research article
Published by Wiley in European Journal of Haematology

Vol. 38 (3) , 274-278
https://doi.org/10.1111/j.1600-0609.1987.tb01176.x

Abstract

In a case of prolymphocytic leukemia (PLL), receptors for interleukin-2 (IL-2R) were demonstrated by immunofluorescence with a monoclonal antibody against IL-2R. Highly purified leukemic B-cells, cultured in vitro with recombinant IL-2 (r-IL-2), responded to IL-2 with a marked increase of DNA-synthesis. Both spontaneous and r-IL-2-induced proliferation of leukemic cells were totally abrogated by the anti-IL-2R monoclonal antibody.

Keywords

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