Antibodies mediating type I skin test reactions to polysaccharide and protein antigens of Candida albicans

Abstract
Immediate, type I, prick test reactions in man to purified fractions of C. albicans group A were mediated by different classes of antibody. The allergens were the cell-wall polysaccharide, mannan, and a purified cytoplasmic protein fraction, free of mannan, prepared by passage through Sepharose-concanavalin-A. Passive transfer tests in the [Rhesus] monkey gave immediate reactions to the purified, cytoplasmic protein, mediated by heat-labile long-term sensitizing antibody, and to mannan, mediated by heat-stable short-term sensitizing antibody.