Urea-Inorganic Phosphate Mixtures as Prebiotic Phosphorylating Agents
- 5 February 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 171 (3970) , 490-494
- https://doi.org/10.1126/science.171.3970.490
Abstract
Previous attempts to phosphorylate nucleosides by heating with inorganic phosphate succeeded only when acid phosphates such as Ca(HPO 4 ) 2 were used. The addition of urea and ammonium chloride to the reaction mixture permits phosphorylation in high yield with neutral or basic phosphates at temperatures in the range of 65° to 100°C. Since the abundant mineral, hydroxylapatite, is a satisfactory substrate for this reaction, we believe that this procedure provides a plausible model for prebiotic phosphorylation.Keywords
This publication has 10 references indexed in Scilit:
- Selective phosphorylation of the cis-2', 3'-diol of unprotected ribonucleosides with trimetaphosphate in aqueous solutionThe Journal of Organic Chemistry, 1970
- Phosphorylation of D-ribose in aqueous solutionThe Journal of Organic Chemistry, 1969
- Prebiotic Synthesis: Phosphorylation in Aqueous SolutionScience, 1968
- Zur Chemie der kondensierten Phosphate und Arsenate, LIII. Das Trimetaphosphat als Triphosphorylierungsmittel für Alkohole und Kohlenhydrate in wäßriger Lösung. Seine Sonderstellung unter den kondensierten PhosphatenEuropean Journal of Inorganic Chemistry, 1967
- Motility of the Turtle Embryo, Chelydra serpentina (Linne)Science, 1967
- Motility of the Turtle Embryo, Chelydra serpentina (Linné)Science, 1967
- Synthesis of Complex Organic Compounds from Simple Precursors: Formation of Amino-Acids, Amino-Acid Polymers, Fatty Acids and Purines from Ammonium CyanideNature, 1963
- Carbodiimides. VIII.1 Observations on the Reactions of Carbodiimides with Acids and Some New Applications in the Synthesis of Phosphoric Acid EstersJournal of the American Chemical Society, 1958
- An Emergency LeucotomyBMJ, 1950
- Chemical Reactions in Fertilizer Mixtures: Effect of Ammoniation on Urea Component of Superphosphate MixturesIndustrial & Engineering Chemistry, 1937