Rhabdoid tumor of the kidney with humoral hypercalcemia and parathyroid hormone‐related protein production

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Abstract
This is a report of a 7‐month‐old infant with malignant rhabdoid tumor of the kidney (RTK). The patient (pt) demonstrated clinical and biochemical evidence of humoral hypercalcemia of malignancy (HHM). The hypercalcemia responded promptly to calcitonin treatment and tumor removal. Despite aggressive surgery and chemotherapy, the patient expired four months after diagnosis. The primary tumor displayed adenylate cyclase‐stimulating activity (ACSA) indicating the production of parathyroid hormone‐related protein (PTHrP) by the primary tumor. This is the first report of ACSA documented in a pt with RTK.