The Effect of Food on the Oral Absorption of Penicillin V Preparations in Children

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Abstract
The oral absorption of pc V in different preparations, given at various times before and after a meal, was investigated in children with upper respiratory infections. The best absorption with respect to peak concentration was observed when potassium pc V (Calciopen®) was given after at least two hours of fasting with no food intake within the following hour. Shorter periods of fasting (1,1/2,0 hrs) before drug intake resulted in significantly lower plasma concentrations. When drug intake was followed by a meal, the absorption was also decreased to some extent. When pc V was given in an oil suspension (Fenoxypen®), or in a small volume (Roscopenin®) together with a meal, the peak concentration was significantly lower than when pc V was given in an aqueous solution with a larger volume (Calciopen®).