Effects of antibiotics on adhesion of enterotoxigenicEscherichia coli strains

Abstract
Subinhibitory concentrations of 28 antibiotics were tested for their effects on MRHA patterns of four enterotoxigenicEscherichia coli strains possessing colonization factor antigens CFA/I, CFA/II or CFA/III. Only penicillin G, oleandomycin, doxycycline and minocycline inhibited the haemagglutination pattern of threeEscherichia coli strains with CFA/I and CFA/II when added to the medium culture at concentrations ranging from 1/2 to 1/50 of the MIC. At the same concentrations they also decreased the adhesion index of the four strains to human intestinal cells. However, neither the specific agglutination of bacterial cells with CFA antisera nor the production of CFAs was affected.