Interleukin-1 is an astroglial growth factor in the developing brain
Open Access
- 1 February 1988
- journal article
- research article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 8 (2) , 709-714
- https://doi.org/10.1523/jneurosci.08-02-00709.1988
Abstract
The immunomodulator interleukin-1 (IL-1) is found to be an astroglial growth factor during development of the mammalian brain. In vitro studies indicate that ameboid microglia, a class of brain mononuclear phagocytes, are the likely source of IL-1. Examination of different brain regions during development shows IL-1 production only after the appearance of ameboid microglia. These observations suggest that brain mononuclear phagocytes secrete growth factors that regulate normal growth and development of the CNS.This publication has 25 references indexed in Scilit:
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