Content and Uptake of Sodium and Potassium in Bone. Influence of Adrenalectomy, Aldosterone, Desoxycorticosterone and Spironolactone1

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Abstract
The effects have been studied in the rat of adrenalectomy and of treatment with aldosterone, desoxycorticosterone acetate and spironolactone upon the content of stable sodium and potassium in compact bone. Simultaneously, the effects of these maneuvers upon the in vivo bone uptake of radioactive sodium and radioactive potassium were determined. Treatment with either aldosterone or desoxycorticosterone results in decreased bone uptake of Na22 and K42. This is a reproducible phenomenon whether the plasma level of isotope increases, decreases or remains unchanged. Total stable bone sodium does not fall significantly upon administration of mineralocorticoids for 15 days. Treatment with a spironolactone, Aldactone, is associated with increased bone uptake of Na22. These results indicate that aldosterone plays a role in regulating the transfer of electrolytes between bone and extracellular fluid.