Comparative Activity of Isologous Vs. Homologous or Heterologous Mouse Bone Marrow in Promoting Regeneration of the Irradiated Mouse Thymus

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Abstract
It was shown that strain C3H, Bagg A, and C3H x C57BL F1 hybrid mice all exhibit a phenomenon previously noted in C57BL mice, namely that either the shielding of one thigh during periodic whole-body irradiation or the intravenous injection of isologous bone marrow immediately after the last irradiation promotes early recovery of thymic weight. The factor in bone marrow responsible for thymic weight regeneration is highly strain-specific: isologous marrow is consistently effective, whereas homologous and heterologous marrow give no evidence of activity. This was best demonstrated by the cross-responses of F1 hybrids and their parent strains to hybrid versus parental marrow. The disparity between these results and those of other investigators, in which heterologous marrow afforded partial protection against radiation mortality, is discussed.