Studies on peptides. CLXV. Combination of a new amide-precursor reagent and trimethylsilyl bromide deprotection for the 9-fluorenylmethyloxycarbonyl-based solid-phase synthesis of chicken antral peptide.
- 1 January 1988
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 36 (12) , 4989-4992
- https://doi.org/10.1248/cpb.36.4989
Abstract
A 36-residue peptide amid corresponding to the entire amino acid sequence of chicken antral peptide was synthesized by the 9-fluorenylmethyloxycarbonyl (Fmoc)-based solid-phase synthesis, for which a new amide precursor reagent, 3-(.alpha.-Fmoc-amino-4-methoxybenzyl)-4-methoxyphenylpropionic acid, was employed in combination with thioanisole-mediated trimethylsilyl bromide deprotection. A homogeneous standard sample prepared by the solution-phase method was used to check the effectiveness of the purification step.This publication has 1 reference indexed in Scilit:
- Peptide synthesis. Part 2. Procedures for solid-phase synthesis using Nα-fluorenylmethoxycarbonylamino-acids on polyamide supports. Synthesis of substance P and of acyl carrier protein 65–74 decapeptideJournal of the Chemical Society, Perkin Transactions 1, 1981