Metabolism of Bis(Tributyltin)Oxide by Estuarine Animals
- 1 January 1986
- conference paper
- Published by Institute of Electrical and Electronics Engineers (IEEE)
- p. 1182-1188
- https://doi.org/10.1109/oceans.1986.1160361
Abstract
A variety of estuarine animals, including crabs (Callinectes sapidus), fish (Leistomus canthurus) and shrimp (Penaeus aztecus), were able to metabolize TBTO which entered the animal via food or water. Hepatic tissues, fish intestine or crab stomach appeared to be important organs for metabolism of TBTO, while the gill, although an important organ for uptake via the water, did not appear to be important in TBTO metabolism. In vivo studies showed dibutyltin to be the major metabolite for these studies. The major TBTO metabolites when using microsomal preparations from fish liver or crab hepatopacreas were beta-hydroxybutyldibutltin and dibutyltin. Oysters (Crassostrea virginica) showed only a limited ability to metabolize TBTO. The cytochrome P-450 dependent mixed-function oxygenase (MFO) system appeared to be the enzyme system responsible for the oxidation of TBTO in microsomes from fish liver and crab stomach. TBTO oxidation by crab stomach or fish liver microsomes required NADPH and oxygen and was inhibited by carbon monoxide.Keywords
This publication has 13 references indexed in Scilit:
- Responses of the mixed function oxidase system of some bivalve and gastropod molluscs to exposure to polynuclear aromatic and other hydrocarbonsMarine Environmental Research, 1985
- Metabolism of a model environmental carcinogen by bivalve molluscsMarine Environmental Research, 1985
- Catalytic properties of cytochrome P-450 in hepatopancreas of the spiny lobster, Panulirus argusMarine Environmental Research, 1984
- Multiple isozymes of hepatic cytochrome p-450 from the marine teleost fish scup (Stenotomus chrysops)Marine Environmental Research, 1984
- Responses of cytochromeP-450 systems in marine crab and polychaetes to organic pollutantsAquatic Toxicology, 1981
- Bioaccumulation and Chronic Toxicity of Bis(tributyltin) Oxide (TBTO): Tests with a Saltwater FishPublished by ASTM International ,1981
- MIXED FUNCTION OXYGENASE ACTIVITY IN BLUE CRAB,CALLINECTES SAPIDUS:TISSUE DISTRIBUTION AND CORRELATION WITH CHANGES DURING MOLTING AND DEVELOPMENTThe Biological Bulletin, 1977
- Bioorganotin chemistry. Metabolism of organotin compounds in microsomal monooxygenase systems and in mammalsJournal of Agricultural and Food Chemistry, 1977
- Bioorganotin chemistry: Reactions of tributyltin derivatives with a cytochrome P-450 dependent monooxygenase enzyme systemJournal of Organometallic Chemistry, 1976
- Petroleum Hydrocarbons: Uptake and Discharge by the Marine Mussel Mytilus edulisScience, 1972