UCP3 in muscle wasting, a role in modulating lipotoxicity?
Open Access
- 5 September 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (22) , 5172-5176
- https://doi.org/10.1016/j.febslet.2006.08.066
Abstract
UCP3 has been postulated to function in the defense against lipid‐induced oxidative muscle damage (lipotoxicity). We explored this hypothesis during cachexia in rats (zymosan‐induced sepsis), a condition characterized by increased oxidative stress and supply of fatty acids to the muscle. Muscle UCP3 protein content was increased 2, 6 and 11 days after zymosan injection. Plasma FFA levels were increased at day 2, but dropped below control levels on days 6 and 11. Muscular levels of the lipid peroxidation byproduct 4‐hydroxy‐2‐nonenal (4‐HNE) were increased at days 6 and 11 in zymosan‐treated rats, supporting a role for UCP3 in modulating lipotoxicity during cachexia.Keywords
This publication has 33 references indexed in Scilit:
- Both oxidative and nitrosative stress are associated with muscle wasting in tumour‐bearing ratsFEBS Letters, 2005
- Activation of UCPs gene expression in skeletal muscle can be independent on both circulating fatty acids and food intakeFEBS Letters, 2005
- Skeletal muscle wasting and contractile performance in septic ratsMuscle & Nerve, 2004
- Uncoupling protein 3 as a mitochondrial fatty acid anion exporterThe FASEB Journal, 2003
- Hyperlipemia: a role in regulating UCP3 gene expression in skeletal muscle during cancer cachexia?FEBS Letters, 2001
- In the rat, tumor necrosis factor α administration results in an increase in both UCP2 and UCP3 mRNAs in skeletal muscle: a possible mechanism for cytokine‐induced thermogenesis?FEBS Letters, 1998
- Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia modelFEBS Letters, 1998
- Derangement in aerobic and anaerobic energy metabolism in skeletal muscle of critically ill and recovering ratsBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1996
- Mitochondrial DNA mutations in human degenerative diseases and agingBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1995
- Rheumatoid cachexia: cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation.Journal of Clinical Investigation, 1994