INHIBITION OF GASTRIC MOTILITY ASSOCIATED WITH THE PRESENCE OF PRODUCTS OF PROTEIN HYDROLYSIS IN THE UPPER SMALL INTESTINE

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Abstract
The list of substances (fat, carbohydrate, HC1, etc.) capable of causing gastric inhibition when placed in the upper small intestine was extended to include various products of protein digestion. Among the numerous materials investigated and found to cause gastric inhibition when placed in the intestine in neutral soln. were: commercial peptones, the intestinal contents obtained from dogs during meat digestion, various enzyme and acid digests of casein prepared in vitro, the separated proteose and proteose-free fractions of several of the above, various individual amino acids and amino acid mixtures. Some of the individual amino acids were ineffective. The gastro-inhibitory effects of all the substances studied were qualitatively similar and resembled the effect of HC1. Some quantitative differences in activity were observed but not explained; apparently they were not correlated with the hydrolytic agent used nor with the degree of hydrolysis. The minimal latent period for gastric inhibition in these expts. was about 15 sec. No gastro-inhibitory effects were observed after double cervical vagotomy, in expts. limited to 2 animals and 2 of the commercial peptones. The products of protein hydrolysis caused inhibition of gastric motility by acting in the intestine as stimuli for the entero-gastric reflex.

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