Synthesis of GD3 as a 4-Methyl-3-pentenyl Glycoside and Subsequent Conjugation to HSA
- 1 July 1994
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 13 (5) , 777-797
- https://doi.org/10.1080/07328309408011680
Abstract
The total synthesis of the tetrasaccharide sequence of the ganglioside GD3 (α-D-Neup5Ac-(2→8)-α-D-Neup5Ac-(2→3)-β-D-Galp-(1→4)-β-D-Glcp-) as the 4-methyl-3-pentenyl glycoside (13) has been accomplished in a relatively straightforward manner. This derivative displays reasonable 1H NMR characteristics in D2O and has subsequently been coupled to a carrier protein by employing the ozonolysis-reductive amination procedure.Keywords
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