EFFECTS OF PROLONGED POISONING BY. RUSSELL'S VIPER VENOM ON BLOOD COAGULATION, PLATELETS AND FIBRINOLYSIS
- 1 January 1984
- journal article
- research article
- Published by Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis in Japanese Journal of Medical Science and Biology
- Vol. 37 (1) , 1-7
- https://doi.org/10.7883/yoken1952.37.1
Abstract
The effects of Russell''s viper venom on blood coagulation, platelets and the fibrinolytic enzyme system were studied in rabbits after injecting repeated doses of 0.05 MLD [minimum lethal dose] of the venom. Thrombocytopenia was the earliest change. It was followed by a rise in serum fibrinogen degradation products and prolongation of prothrombin time, activated partial thromboplastin time and thrombin time indicating a progressive consumption coagulopathy and activation of fibrinolysis. Red blood cell morphology was unchanged during the 1st 3 wk; the fragmentation appeared after the 4th wk and it increased in severity with further envenomations, i.e., when chronic DIC [disseminated intravascular coagulation] was established.This publication has 6 references indexed in Scilit:
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