EFFECT OF CERTAIN CHOLERETIC AGENTS ON EXCRETION OF PIGMENT AND BROMSULFALEIN IN BILE

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Abstract
The effect of Na dehydrocholate, Na cinchophen and Na cholate on the rate of bile flow and biliary excretion of endogenous and exogenous bilirubin and of bromsulfalein was studied in cholecystectomized dogs provided with gastric and duodenal fistulae fitted with large cannulae. The increased bile flow induced by these agents was accompanied by an increase in bile pigment excretion. In the case of Na cholate, this was attributed to the attendant intravascular hemolysis and consequent hemo-globinemia. In the case of Na dehydrocholate, the increased pigment output could be attributed to flushing of the "dead space" of the bile duct system of its pre-injn. pigment content. This phenomenon did not appear to afford an adequate explanation for the augmented pigment output following admn. of Na cinchophen. Biliary excretion of exogenous bilirubin was neither accelerated nor retarded by simultaneous intraven. injn. of either Na dehydrocholate or Na cinchophen. Biliary excretion of BSP was not affected by Na cinchophen but was delayed somewhat by Na dehydrocholate, being temporarily suppressed during the period of max. choleresis and increasing subsequently. After admn. of Na cholate the 3-hr. excretion of BSP was reduced to about 50% or less of the control values.

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