The TNFd4 allele is correlated to moderate-to-severe acute graft-versus-host disease after allogeneic stem cell transplantation

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Abstract
Summary. Certain cytokine gene polymorphisms may be associated with severe acute graft‐versus‐host disease (GVHD) after allogeneic stem cell transplantation. The present study analysed 196 patients and their donors for TNF−308, TNFd, IL‐10−1064 and IL‐10−1082 gene polymorphisms. Serum analysis of tumour necrosis factor‐α (TNF‐α) and interleukin 10 (IL‐10) levels during conditioning therapy was also performed. Among patients with sibling donors, the TNFd allele 4 was significantly correlated with acute GVHD grades II–IV (P < 0·01). Acute GVHD grades II–IV were more common among patients homozygous for the IL‐10−1064 allele 13 (P = 0·02). Patients homozygous for the TNF−308 allele (AA) correlated with higher TNF‐α serum levels during conditioning (P = 0·02).