Human polyomavirus JC virus genome

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Abstract
The complete DNA sequence of the human JC virus, consisting of 5130 nucleotide pairs, is presented. The amino acid sequence of 6 proteins could be deduced: the early, nonstructural proteins, large T and small t antigens; the late capsid proteins, VP1, VP2 and VP3: and the agnogene product encoded within the late leader sequence, called the agnoprotein in SV40. The extent of homology between JC virus DNA and the genomes of SV40 (69%) and BK virus (75%) confirmed the close evolutionary relationship of these 3 polyomaviruses. The sequences showing the greatest divergence in these viral DNA occurred within the tandem repeats located to the late side of the replication origins.