Experimental Glioma in Primates: A Computed Tomography Model

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Abstract
Owl and squirrel monkeys inoculated intracerbrally with human polyomavirus obtained from the brain of a patient with progressive multifocal leukoencephalopathy developed cerebral gliomas. Among these tumors, 3 of 5 were detected and accurately localized by contrast enhanced computed tomography (CT) when the animals were still clinically normal. Various CT features of these tumors corresponded to specific pathologic changes, such as histologic type and presence and hemorrhage and necrosis. Tumor progression was clearly demonstrated in repeat scans of 1 animals. The CT sensitivity and the capability of distinguishing various pathologic features are encouraging. It appears that a much needed, suitable model of experimental cerebral tumors in primates is now available for CT studies.