Re-evaluation of LG V of the rat and assignment of 12 carboxylesterases to two gene clusters
- 1 March 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Heredity
- Vol. 78 (2) , 92-96
- https://doi.org/10.1093/oxfordjournals.jhered.a110343
Abstract
Examining the strain distribution pattern of the recombinant Inbred strain series LXB and DXE and of backcross progeny of (LEW×LE) F1 × LEW, (LEW×BN) F1 × LEW, and (LEW×BN) F1 × BN for esterase markers, including three carboxylesterase allozymes (ES-15, ES-16, ES-18), hitherto not studied genetically, revealed the existence of two esterase gene clusters within LG V: cluster 1, containing Es-2, Es-8, Es-10, Es-3, Es-7, Es-9, and separated by 8.8 ± 1.3 cM from cluster 2, containing Es-1, Es-14 (formerly Es-SI), Es-15, Es- 16, and Es-18. Analyses of 93 inbred strains of rats showed only 12 and 6 haplotypes for cluster 1 and cluster 2, respectively, Indicating a strong linkage disequilibrium. These data and serotyping results of one backcross population for the RT2 blood group system lead to a re-evaluation of linkage group V. Including literature data the following gene order is suggested: RT2 – (7.1 ± 1.8) Es-2, Es-4, Es-8, Es-10 (2.7 ± 0.7) Es-3, Es-7, Es-9 (8.8 ± 1.3) Es-7, Es-14, Es-15, Es-16, Es-18.This publication has 10 references indexed in Scilit:
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