The Role of Bile in Calcium Absorption

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Abstract
The influence of biliary secretion on calcium absorption from the intestine was investigated using intraperitoneal doses of sodium taurocholate to stimulate bile flow. The femur content of Ca45 24 hours after administration of an oral dose of labeled calcium was used as criteria for absorption. Sodium taurocholate injected intraperitoneally significantly increased the absorption of calcium from the intestine. The effect was produced in young and mature female rats, and young male rats. Ligation of the bile duct removed the stimulatory effect of intraperitoneal sodium taurocholate upon calcium absorption. Sodium taurocholate fed orally to young female rats significantly increased calcium absorption at a calcium: sodium taurocholate ratio of 2:1. Bile duct ligation prevented an increased absorption. Sodium taurocholate given intraperitoneally had no influence upon the distribution of Ca45 injected intraperitoneally. No significant changes in intestinal pH were seen when bile flow was stimulated. The stimulatory effect of L-lysine upon calcium absorption could not be abolished by bile duct or bile-pancreatic duct ligation.

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