Diagnosing norovirus-associated infectious intestinal disease using viral load
Open Access
- 14 May 2009
- journal article
- Published by Springer Nature in BMC Infectious Diseases
- Vol. 9 (1) , 63
- https://doi.org/10.1186/1471-2334-9-63
Abstract
Reverse transcription-polymerase chain reaction (RT-PCR) is the main method for laboratory diagnosis of norovirus-associated infectious intestinal disease (IID). However, up to 16% of healthy individuals in the community, with no recent history of IID, may be RT-PCR positive; so it is unclear whether norovirus is actually the cause of illness in an IID case when they are RT-PCR positive. It is important to identify the pathogen causing illness in sporadic IID cases, for clinical management and for community based incidence studies. The aim of this study was to investigate how faecal viral load can be used to determine when norovirus is the most likely cause of illness in an IID case.Keywords
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