Phenotypic Alterations in Adrenal Tumor Cultures
- 25 June 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 148 (3678) , 1733-1734
- https://doi.org/10.1126/science.148.3678.1733
Abstract
Adrenal tumor cells in culture gradually develop a requirement for glutamine and serum albumin in order to produce steroids in response to adrenocorticotropic hormone. Glutamine acts simply as a precursor for a protein or proteins whose synthesis is required for the response to the hormone. Albumin apparently binds steroid hormone products that otherwise would inhibit further biosynthesis of steroids.This publication has 7 references indexed in Scilit:
- Studies in vitro on single beating rat-heart cellsBiochimica et Biophysica Acta (BBA) - General Subjects, 1964
- Studies in vitro on single beating rat-heart cellsBiochimica et Biophysica Acta (BBA) - General Subjects, 1964
- Protein Synthesis and Adrenocorticotropin ResponsivenessJournal of Biological Chemistry, 1963
- HORMONE-PRODUCING CULTURES OF ADRENAL AND PITUITARY TUMOR ORIGINProceedings of the National Academy of Sciences, 1962
- Functional biochemical changes in bovine mammary cell culturesExperimental Cell Research, 1961
- THE LOSS OF PHENOTYPIC TRAITS BY DIFFERENTIATED CELLS IN VITRO, I. DEDIFFERENTIATION OF CARTILAGE CELLSProceedings of the National Academy of Sciences, 1960
- Preparation and Properties of Serum and Plasma Proteins. XIII. Crystallization of Serum Albumins from Ethanol-Water Mixtures1a,bJournal of the American Chemical Society, 1947