MR flow mapping of dobutamine‐induced changes in diastolic heart function

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Abstract
Purpose To evaluate the ability of MR flow mapping to measure changes in left ventricular filling during β‐adrenergic stimulation. Materials and Methods Mitral flow was measured in 10 healthy volunteers using conventional free breathing fast‐field echo (FFE) with a spatial resolution of 2.7 × 2.2 mm and a temporal resolution of 22 msec. The sequence was repeated during dobutamine infusion (20 μg/kg/minute). Results Stroke volume increased from a median of 99 mL (range: 68–142 mL) (Note: values as presented are medians and ranges, throughout) to 114 mL (87–180 mL) (P < 0.05). Both early (E) peak filling rate (554 mL/second [433–497 mL] to 651 mL/second [496–1096 mL/second]) (P < 0.05) and atrial (A) peak filling rate (238 mL/second [183–352 mL/second] to 341 mL/second [230–538 mL/second]) (P < 0.05) increased. These changes, together with the increase in E acceleration peak and A deceleration peak, were consistent with facilitated myocardial relaxation. Conclusion Conventional free breathing FFE has the ability to measure the effects of β‐adrenergic stimulation on left ventricular filling. J. Magn. Reson. Imaging 2004;19:176–181.