T‐cell acute lymphoblastic leukaemia with late developing Philadelphia chromosome

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Abstract
A case of childhood T-cell acute lymphoblastic leukemia (ALL) is presented in which the only chromosome abnormality at diagnosis was a deletion of part of the short arm of one chromosome 9 (9p-). Cytogenetic studies at relapse showed, in addition to 9p-, a partial deletion of the long arm of one chromosome 6 (6q-) and the Philadelphia chromosome (Ph1) produced as a result of the classical translocation t(9q+; 22q-). All metaphases from hemopoietic colonies grown from a cryopreserved specimen of this patient''s marrow at relapse were normal, in contrast to hemopoietic colonies cultured from patients with chronic myelogenous leukemia (CML) which contained the Ph1. A hypothesis which incorporates T-cell ALL with late development of the Ph1 into the overall family of Ph1 positive diseases is suggested.