Antiinflammatory principle of Ephedra herbs.
- 1 January 1980
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 28 (10) , 2900-2904
- https://doi.org/10.1248/cpb.28.2900
Abstract
Since the traditional usage of an Oriental medicine mao, consisting of Ephedra herbs, suggests that it may possess antiinflammatory activity, a crude drug preparation, the aerial part of E. intermedia, was subjected to bioassay for antiinflammatory activity by 2 methods. The methanol extract was active. The extract was fractionated in monitoring the antiinflammatory activity, resulting in the isolation of (+)-pseudoephedrine as the active principle. The antiinflammatory effects of ephedrine analogs were determined by 4 assay methods; pseudoephedrine exhibited the strongest activity in the Whittle method, the carrageenan paw edema method in mice and the fertile egg method.This publication has 3 references indexed in Scilit:
- Maokonine, Hypertensive Principle of Ephedra Roots1Planta Medica, 1978
- DIE GERBSTOFFBILDNER INEPHEDRA HELVETICAPlanta Medica, 1976
- THE USE OF CHANGES IN CAPILLARY PERMEABILITY IN MICE TO DISTINGUISH BETWEEN NARCOTIC AND NONNARCOTIC ANALGESICSBritish Journal of Pharmacology and Chemotherapy, 1964