Renal Reabsorption of Bicarbonate

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Abstract
The renal tubular reabsorption of bicarbonate was studied in dogs over a wide range of plasma bicarbonate concns., and an essentially constant rate of reabsorption of 2.5 m[image]/100 ml. of glomerular filtrate was found when the plasma bicarbonate concn. was elevated, a result in agreement with the data previously reported by Pitts and Lotspeich. The absolute reabsorption of bicarbonate remains essentially constant when glomerular filtration rate is acutely reduced, whereas the quantity reabsorbed per unit vol. of glomerular filtrate rises progressively as the filtration rate falls. In this situation the reabsorption of bicarbonate resembles that of glucose and appears to be governed by a Tm mechanism.

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