Ischemic colitis in rats

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Abstract
Left-sided ischemic colitis was induced in 44 inbred Male Fischer rats of the same age by a standardized devascularization procedure. Fifteen animals had nothing else done (group 1). Animals had feces evacuated from the left colon and received an enema just before the procedure; 14 had sterile-water enema (group 2) and 15 had a 1% hydrocortisone enema (group 3). At sacrifice, 72 h after the surgical procedure, the mucosal surface grossly involved in ischemic changes was measured. The mean area of ischemic changes in group 1 was significantly greater than that of either group 2 or group 3 (P < 0.05). The incidence of circumferential changes was highest in group 1 and lowest in group 3; the difference between group 1 and group 3 was marginally significant (P = 0.06).