Chondromodulin I Is a Bone Remodeling Factor
Open Access
- 1 January 2003
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 23 (2) , 636-644
- https://doi.org/10.1128/mcb.23.2.636-644.2003
Abstract
Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I−/− mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I−/− mice. Thus, the present study established that ChM-I is a bone remodeling factor.Keywords
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