The Influence of Dietary Factors upon the Therapeutic Activity of Sulfanilamide in Mice

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Abstract
Wide variations in the therapeutic activity of sulfanilamide upon streptococcal infections were observed in mice upon diets of varying protein content. Protein was antagonistic to the action of sulfanilamide and the therapeutic response varied inversely with the protein content. Mice upon low protein diets showed higher concs. of sulfanilamide in the blood. While pronounced variations in the degree of acetylation or rate of excretion could not be detected, a definite retention of phenolsulfonephthalein in the blood was observed on low protein diets, indicating that impaired renal function is an important factor.

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