Abstract
The details and principles of construction and operation of a tail plethysmograph for blood pressure measurement in the intact mouse have been described. The indirect method of blood pressure measurement has been validated by comparison with simultaneously recorded direct measurements of mean blood pressure over a range of pressures and temps. in several mice. The tail plethysmograph method of blood pressure measurement in the mouse is not invalidated by working at room temp. However, the true blood pressure is altered by tail temp. changes in the range between 20 and 43 C.

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