REGIONAL DIFFERENCES IN THE GROWTH OF SKIN TRANSPLANTS

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Abstract
It was reported that marked differences exist in the relative growth rate of tumors transplanted i.d. [intradermally] or s.c. [subcutaneously] into different regions of the mouse trunk. This research was undertaken to determine whether or not these regional differences applied uniquely to tumor tissue or whether there existed a more basic underlying principle influencing normal tissue growth. As a test system we used skin transplants between histocompatible C57BL/6J and C57BL/6-c2J mice. Grafts were placed middorsally in the thoracic or lumbar region and compared for rate of healing in, skin retraction, growth and hair formation. A marked differential in the establishment and growth of skin grafts was seen: anteriorly placed skin transplants resulted in larger grafts than did similar transplants placed more posteriorly. Apparently there are basic physiological differences between the more anterior and posterior regions of the trunk that are reflected in the relative growth and maintenance of tissue transplants.