Immunoreactive Vasoactive Intestinal Polypeptide in Rat Hypophysial Portal Blood
- 1 February 1981
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 108 (2) , 395-398
- https://doi.org/10.1210/endo-108-2-395
Abstract
Vasoactive intestinal polypeptide (VIP) was measured by RIA in the hypophysial portal blood of rats after total hypophysectomy. The mean (±SE) VIP concentrations were 1332±171 pg/ml (range, 300-3868 pg/ml) under urethane anesthesia and 1735±707 pg/ml under pentobarbital anesthesia. The concentrations of VIP in peripheral plasma were, in most animals, less than 100 pg/ml. The secretion rate of VIP was not considerably changed during the blood collection. Immunoreactive VIP in hypophysial portal blood was identical to authentic VIP on gel chromatography. These findings suggest that VIP secreted from the hypothalamus may modulate pituitary function via the portal circulation.Keywords
This publication has 11 references indexed in Scilit:
- Radioimmunologic localization of vasoactive intestinal polypeptide in hypothalamic and extrahypothalamic sites in the rat brainNeuroscience Letters, 1979
- Vasoactive Intestinal Peptide: Evidence for a Hypothalamic Site of Action to Release Growth Hormone, Luteinizing Hormone, and Prolactin in Conscious Ovariectomized Rats*Endocrinology, 1979
- Vasoactive intestinal polypeptide: Release into hypophyseal portal bloodLife Sciences, 1979
- Prolactin Release by Vasoactive Intestinal Polypeptide in Rats*Endocrinology, 1978
- Hypothalamic-Pituitary Vasculature: Evidence for Retrograde Blood Flow in the Pituitary Stalk1Endocrinology, 1977
- Localization of vasoactive intestinal polypeptide (VIP) to central and peripheral neurons.Proceedings of the National Academy of Sciences, 1976
- Vasoactive Intestinal Polypeptide: Abundant Immunoreactivity in Neural Cell Lines and Normal Nervous TissueScience, 1976
- POSSIBLE DUAL ROLE FOR VASOACTIVE INTESTINAL PEPTIDE AS GASTROINTESTINAL HORMONE AND NEUROTRANSMITTER SUBSTANCEThe Lancet, 1976
- Collection of Hypophysial Stalk Blood in RatsEndocrinology, 1967
- THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITYBiochemical Journal, 1963