Congenital Hemorrhagic Diathesis with Deficiency of Factor XIII

Abstract
A male patient with a severe congenital bleeding disorder due to factor XIII deficiency is described. An extensive family study revealed no additional demonstrable deficiencies of this factor. A lowered fibrinogen level in four of the father’s relatives was found, and remained unexplained. Prophylactic treatment with plasma transfusions appeared to be effective. * Present address : Department of Medicine, University of Wisconsin, 1300 University Avenue, Madison, Wisconsin 53706 USA.