SERUM AMYLOID P-COMPONENT AS A MARKER OF LIVER-DISEASE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 77  (6) , 427-430
Abstract
The P-component of amyloid is a normal serum protein designated SAP. In view of recent in vivo experiments that have suggested a possible role for the liver in the synthesis of SAP, the usefulness of its serum level as a marker of liver involvement was evaluated. The study included 198 healthy adults, 154 patients with liver diseases and 27 HBsAg (hepatitis B surface antigen) carriers. Normal serum level of SAP was 66.12 .mu.g/ml for males and 57.17 .mu.g/ml for females. Patients with liver disease had a significantly decreased level of SAP. The mean serum level of SAP in cirrhosis was 30.15; in chronic active hepatitis, 37.16; and in acute hepatitis, 44.86 .mu.g/ml. Asymptomatic HBsAg carriers had a normal SAP level (mean 65.48 .mu.g/ml). Patients (32) with acute hepatitis were tested during the acute stage of the disease and after complete recovery. In all but 3 patients, a significant increase in SAP level, from a mean of 35.8-58.48 .mu.g/ml, was observed. A close correlation between serum levels of SAP and the degree of disease activity and hepatic impairment in patients with liver diseases, especially in those with acute hepatitis, is suggested. Repeat determinations of SAP in patients with liver diseases could possibly help in their routine management.