Experimental Internal Iliac Artery Embolization: Evaluation of Low Viscosity Silicone Rubber, Isobutyl 2-Cyanoacrylate, and Carbon Microspheres

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Abstract
The angiographic, morphologic and histologic effects of carbon microspheres, isobutyl 2-cyanoacrylate (IBC) and low viscosity silicone rubber (LVSR) were compared. C spheres did not effectively occlude the internal iliac artery, but resulted in small vessel occlusions leading to the most frequent complications. IBC was effective in causing occlusion but resulted in significant inflammatory changes within the thrombus and vessel wall. LVSR gave satisfactory occlusion without inciting vessel wall inflammatory reaction. Of 4 animals 2 developed a hind extremity paralysis. None of these materials are approved for general intravascular usage.