Interferon Action: RNA Cleavage Pattern of a (2′-5′)Oligoadenylate—Dependent Endonuclease
- 29 May 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 212 (4498) , 1030-1032
- https://doi.org/10.1126/science.6165080
Abstract
One of the mediators of interferon action is a latent endoribonuclease (ribonuclease L) that is activated by (2'-5')oligoadenylates. Among the homopolymers of the four common ribonucleotides, activated ribonuclease L degrades at an appreciable rate only polyuridylic acid. In two natural RNA's tested the most frequent ribonuclease L cleavages occur after UA, UG, and UU (A, adenine; U, uracil; and G, guanine) and much less frequent cleavages after CA and AC (C, cytosine).This publication has 19 references indexed in Scilit:
- Splicing of yeast tRNA precursors: a two-stage reactionCell, 1979
- Interferon action: Isolation of Nuclease F, A translation inhibitor activated by interferon‐induced (2′–5′) oligo‐isoadenylateFEBS Letters, 1978
- Interferon action may be mediated by activation of a nuclease by pppA2′p5′A2′p5′ANature, 1978
- Interferon, double-stranded RNA and RNA degradation. Fractionation of the endonucleaseINT system into two macromolecular components; Role of a small molecule in nuclease activationBiochemical and Biophysical Research Communications, 1978
- Characteristics of Extracts from Interferon-treated HeLa Cells: Presence of a Protein Kinase and Endoribonuclease Activated by Double-stranded RNA and of an Inhibitor of mRNA MethylationJournal of General Virology, 1977
- Interferon, Double‐Stranded RNA and RNA DegradationEuropean Journal of Biochemistry, 1977
- Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cellsNature, 1977
- Interferon, double-stranded RNA and mRNA degradationNature, 1976
- Increased endonuclease activity in an extract from mouse Ehrlich ascites tumor cells which had been treated with a partially purified interferon preparation: Dependence on double-stranded RNABiochemical and Biophysical Research Communications, 1976
- Sequence of 51 nucleotides at the 3′-end of R17 bacteriophage RNAJournal of Molecular Biology, 1972