COMPARTMENTAL AND NONCOMPARTMENTAL PHARMACOKINETIC ANALYSES OF MINOCYCLINE HYDROCHLORIDE IN THE DOG

  • 1 January 1985
    • journal article
    • research article
    • Vol. 46  (6) , 1316-1318
Abstract
Six adult dogs were given 5 mg of [the antiinfective drug] minocycline hydrochloride/kg of body weight i.v. Pharmacokinetic evaluation of the serum drug concentration versus time data was performed, using the 2-compartment open model, the 3-compartment open model, and a noncompartmental model involving use of the statistical moment theory. All pharmacokinetic values except clearance were model independent. Minocycline half-life ranged between 6.48 and 7.24 h; volume of distribution at steady state, between 1.859 .+-. 0.358 and 2.001 .+-. 0.468 l/kg; and clearance, between 3.195 .+-. 0.618 and 3.424 .+-. 0.684 ml/min per kg. These data are similar to those reported for oxytetracycline and indicate that the frequency of administration of the 2 tetracyclines should be the same. Of the 6 dogs, 3 developed an adverse response to the i.v. injection of minocycline. Dog 1 developed urticaria and had initial serum drug concentrations of .apprx. 2 times the mean concentrations for the other dogs; values were not included in the pharmacokinetic analysis. Two other dogs had transient signs indicating cardiovascular depression or hypotension; their data were included. Due to the frequency of the unexpected reactions found in this study, it was concluded that dogs should not be given minocycline rapidly i.v.