IN VIVO AND IN VITRO STUDIES ON THE EFFECT OF METOCLOPRAMIDE ON ALDOSTERONE SECRETION
- 1 September 1980
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 13 (1) , 45-50
- https://doi.org/10.1111/j.1365-2265.1980.tb01021.x
Abstract
SUMMARY: Metoclopramide, a dopamine antagonist drug, elevated plasma aldosterone and prolactin levels without significantly affecting plasma renin activity, ACTH or potassium. Studies with isolated perfused rat zona glomerulosa cells showed that metoclopramide could directly stimulate aldosterone release and that this action was blocked by dopamine. These results suggest that dopamine may play an important inhibitory role in the control of aldosterone secretion.This publication has 9 references indexed in Scilit:
- Effects of Metoclopramide and Bromocriptine on the Renin-Angiotensin-Aldosterone System in ManJournal of Clinical Investigation, 1979
- The Development and Application of a Direct Radioimmunoassay for Plasma Aldosterone Using125I-Labeled Ligand—Comparison of Three Methods*†Journal of Clinical Endocrinology & Metabolism, 1978
- METOCLOPRAMIDE INCREASES PLASMA ALDOSTERGNE CONCENTRATION IN MANJournal of Clinical Endocrinology & Metabolism, 1977
- EVIDENCE FOR DOPAMINERGIC CONTROL OF THYROTROPHIN SECRETION IN MANThe Lancet, 1977
- Failure of Endogenous Prolactin to Alter Renal Salt and Water Excretion and Adrenal Function in Man*Journal of Clinical Endocrinology & Metabolism, 1976
- INHIBITION OF THE PLASMA-ALDOSTERONE RESPONSE TO FRUSEMIDE BY BROMOCRIPTINEThe Lancet, 1975
- Measurement of the dynamics of stimulation and inhibition of steroidogenesis in isolated rat adrenal cells by using column perfusionBiochemical Journal, 1974
- Letter: Metaclopramide and prolactin.BMJ, 1974
- A Radioimmunoassay for Rat Plasma ACTHEndocrinology, 1971