Effects of Gonadotrophin-Induced Elevation of Serum Testosterone upon Somatomedin C Levels and Serum Thymidine Activity in Children

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Abstract
3H-thymidine uptake into lectin-activated human lymphocytes allows to measure a growth-stimulating activity of serum, the thymidine activity (TA), which is GH dependent in vivo and related to somatomedins (Sm). In this work, it is shown: (1) that addition of human chorionic gonadotrophin (HCG) or testosterone in vitro does not increase the 3H-thymidine uptake into lymphocytes; (2) that the gonadotrophin-induced elevation of testosterone in children is accompanied by a significant increase of TA and, at a lesser degree, of Sm C; (3) that these two increases are significantly correlated, and (4) that the age-related variation of TA and Sm C after HCG stimulation test are not parallel.

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