The effect of tunicamycin on transferrin synthesis and secretion in hormonally stimulated explants of rabbit mammary gland

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Abstract
Pregnant rabbit mammary gland explants cultured with insulin, prolactin and cortisol synthesize and secrete transferrin radiolabelled with [3H]leucine or [ 3H]mannose. Addition of tunicamycin inhibits the glycosylation but not synthesis of the [3H]leucine-labelled poly-peptide. Secretion of the non-glycosylated protein is only marginally inhibited.