Coenzyme Q10, Vitamin E, and Dihydrothioctic Acid Cooperatively Prevent Diene Conjugation in Isolated Low-Density Lipoprotein
- 1 June 2000
- journal article
- research article
- Published by Mary Ann Liebert Inc in Antioxidants and Redox Signaling
- Vol. 2 (2) , 327-333
- https://doi.org/10.1089/ars.2000.2.2-327
Abstract
Coenzyme Q (Q10) and α-tocopherol cooperatively delay the onset of diene conjugation in isolated human low density lipoprotein if supplied in water-soluble preparations to blood serum. Both copper ions and morpholino sydnonimine (in the presence of glucose; SIN-1-glucose) -driven diene conjugation is measurable as soon as both reduced Q10 and tocopherol are oxidized, where tocopherol oxidation starts after 80–90% consumption of reduced Q10. LDL-bound Q10 in turn can be rapidly reduced by dihydrolipoic acid (thioctic acid). This reaction is at least 10 times faster than reduction by ascorbic acid.Keywords
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