Failure of penicillin prophylaxis in laboratory acquired leptospirosis
- 1 March 1988
- journal article
- case report
- Published by Oxford University Press (OUP) in Postgraduate Medical Journal
- Vol. 64 (749) , 236-238
- https://doi.org/10.1136/pgmj.64.749.236
Abstract
A laboratory technician developed leptospirosis following accidental inoculation, despite prompt administration of parenteral penicillin by an accepted regimen of post-exposure prophylaxis. Another technician was similarly exposed and was given doxycycline; no illness or serological conversion followed. The implications of these cases are discussed and recommendations made for post-exposure chemoprophylaxis with doxycycline.Keywords
This publication has 12 references indexed in Scilit:
- The susceptibility of a strain of leptospira interrogans serogroup icterohaemorrhagiae to amoxycillin, erythromycin, lincomycin, tetracycline, oxytetracycline and minocyclineZentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology, 1986
- From the PHLS. Update on leptospirosis.BMJ, 1985
- An Efficacy Trial of Doxycycline Chemoprophylaxis against LeptospirosisNew England Journal of Medicine, 1984
- Doxycycline Prophylaxis for Human Scrub TyphusThe Journal of Infectious Diseases, 1982
- LABORATORY-ASSOCIATED INFECTIONS - SUMMARY AND ANALYSIS OF 3921 CASES1976
- Human LeptospirosisCRC Critical Reviews in Clinical Laboratory Sciences, 1975
- Infection by Leptospira ballumSouthern Medical Journal, 1974
- Typhoid Fever: Pathogenesis and Immunologic ControlNew England Journal of Medicine, 1970
- Leptospirosis ITransactions of the Royal Society of Tropical Medicine and Hygiene, 1967
- Leptospirosis (Ballum) Contracted from Swiss Albino MiceArchives of internal medicine (1960), 1958